Preparation and evaluation of various formulation effects of the second emulsion on the shape and release profile of propranolol <scp>HCl</scp> from ethyl cellulose microparticle blends

The objective of this study was to investigate and characterize incorporated propranolol HCl (Pro) within ethyl cellulose microparticle blends using the solvent evaporation method. were prepared with a water-in-oil-in-water (W/O/W) method contained same drug Propranolol (Pro). first Pro emulsion (W/O) second dispersed in an external aqueous phase, dispersion time interval (DTI) 0 60 min. morphology characterized by SEM. mean particle size, chord length distribution count droplets/hardened microparticles monitored focused beam reflectance measurement (FBRM). encapsulation efficiency vitro release phosphate buffer (pH 7.4) also investigated. resulting spherical, two populations. size ranged from 104.26 μm 127.64 μm. about 76.53% 78.81% for blends. FBRM studies showed that W/O/W DTI min stirring 4 h larger than In after 28 days (54.05%) slower (73.28%). Based on these data, there is interaction primary hard particles emulsion, whereby blocked coated pores surface emulsion. These blocking coating effects depended DTI. conclusion, novel containing drugs solubility offer high potential controlled delivery systems. © 2022 Authors. Polymer International published John Wiley & Sons Ltd behalf Society Industrial Chemistry.